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Showing 1 to 12 of 29 entries
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Immune Modulation in Cancer Patients After Adoptive Transfer of Anti-CD3/Anti-CD28-Costimulated T Cells-Phase I Clinical Trial.

Journal of immunotherapy : official journal of the Society for Biological Therapy

Lum LG, LeFever AV, Treisman JS, Garlie NK, Hanson JP.
PMID: 11685083
J Immunother (1991). 2001 Sep-Oct;24(5):408-419.

Anti-CD3/anti-CD28 monoclonal antibody-coactivated T cells (COACTs) proliferate, secrete tumoricidal cytokines, and mediate non-major histocompatibility complex (MHC)-restricted cytotoxicity. This phase I study was done to determine the safety, maximum tolerated dose, technical limits of expansion, and modulation of immune functions...

Identification of a New Shared HLA-A2.1 Restricted Epitope From the Melanoma Antigen Tyrosinase.

Journal of immunotherapy : official journal of the Society for Biological Therapy

Riley JP, Rosenberg SA, Parkhurst MR.
PMID: 11395636
J Immunother (1991). 2001 May;24(3):212-220.

SUMMARY: Tyrosinase has many advantages as a target antigen for the immunotherapy of patients with melanoma because it is expressed in nearly all melanoma specimens with a high degree of cellular homogeneity, and its distribution in normal tissues is...

Tumor-Dendritic Cell Fusion Technology and Immunotherapy Strategies.

Journal of immunotherapy : official journal of the Society for Biological Therapy

Shu S, Cohen P.
PMID: 11449063
J Immunother (1991). 2001 Mar;24(2):99-100.

No abstract available.

Sustained Release of Granulocyte-Macrophage Colony-Stimulating Factor From a Modular Peptide-Based Cancer Vaccine Alters Vaccine Microenvironment and Enhances the Antigen-Specific T-Cell Response.

Journal of immunotherapy : official journal of the Society for Biological Therapy

Nguyen CL, Bui JT, Demcheva M, Vournakis JN, Cole DJ, Gillanders WE.
PMID: 11685084
J Immunother (1991). 2001 Sep-Oct;24(5):420-429.

SUMMARY: The recent identification and molecular characterization of tumor antigens provides the opportunity to explore the rational development of peptide-based cancer vaccines. However, the response to these vaccines remains variable, and peptide-based cancer vaccines may even produce tolerance induction...

Graft-Versus-Host Alloresponses to Treat Nonlymphohematopoietic Tumors: Is There a Solid Approach?.

Journal of immunotherapy : official journal of the Society for Biological Therapy

Sykes M.
PMID: 11449064
J Immunother (1991). 2001 Mar;24(2):101-103.

No abstract available.

Cell Therapy With Preimmunized Effector Cells Mismatched for Minor Histocompatible Antigens in the Treatment of a Murine Mammary Carcinoma.

Journal of immunotherapy : official journal of the Society for Biological Therapy

Morecki S, Yacovlev E, Gelfand Y, Uzi I, Slavin S.
PMID: 11449067
J Immunother (1991). 2001 Mar;24(2):114-121.

SUMMARY: Cell therapy with allogeneic donor cells mismatched for minor histocompatible (MiHC) antigens was applied to a murine mammary carcinoma (4T1) model to test the feasibility of graft versus tumor (GVT) effect against metastatic epithelial tumor cells. BALB/c mice...

Dendritic Cell Infiltration in Colon Cancer.

Journal of immunotherapy : official journal of the Society for Biological Therapy

Schwaab T, Weiss JE, Schned AR, Barth RJ.
PMID: 11449069
J Immunother (1991). 2001 Mar;24(2):130-137.

We quantitatively evaluated dendritic cell (DC) infiltration in primary colorectal cancers from 44 patients and metastatic colorectal tumors from 13 patients using immunohistochemistry for the DC marker CD83, HLA-DR, and the DC activation molecules CD40 and CD86. Nearly all...

Hierarchy, Tolerance, and Dominance in the Antitumor T-Cell Response.

Journal of immunotherapy : official journal of the Society for Biological Therapy

Restifo NP.
PMID: 11395633
J Immunother (1991). 2001 May;24(3):193-194.

No abstract available.

MHC Class II-Restricted Tumor Antigens Recognized by CD4+ T Cells: New Strategies for Cancer Vaccine Design.

Journal of immunotherapy : official journal of the Society for Biological Therapy

Zeng G.
PMID: 11395634
J Immunother (1991). 2001 May;24(3):195-204.

SUMMARY: The adoptive transfer of tumor-infiltrating lymphocytes (TIL) can mediate tumor regression in patients with melanoma. This finding has led to the identification and characterization of tumor-associated antigens recognized by CD8+ TIL. Several clinical trials based on the genes...

Generation of Cytotoxic T Lymphocytes Specific for Human Cytomegalovirus Using Dendritic Cells In Vitro.

Journal of immunotherapy : official journal of the Society for Biological Therapy

Cho HI, Han H, Kim CC, Kim TG.
PMID: 11395640
J Immunother (1991). 2001 May;24(3):242-249.

SUMMARY: For the adoptive immunotherapy in immunodeficient bone marrow transplant recipients to prevent and treat human cytomegalovirus (HCMV)-associated diseases, HCMV-pulsed dendritic cells (DCs) were used as antigen-presenting cells for the induction of cytotoxic T lymphocytes (CTLs) specific to HCMV...

Polyclonal Antibodies Against gp185HER2 Peptides: Their Putative Role in the Identification of a Particular HER2 Status in Patients With Breast Cancer.

Journal of immunotherapy : official journal of the Society for Biological Therapy

Di Modugno F, Buglioni S, Mottolese M, Del Bello D, Cascioli S, Chersi A, Santoni A, Nisticò P.
PMID: 11395637
J Immunother (1991). 2001 May;24(3):221-231.

SUMMARY: The HER2 oncogene and its relative oncoprotein, gp185HER2, a transmembrane glycoprotein belonging to the epidermal growth factor receptor family, are overexpressed in a wide range of solid tumors including breast and ovarian cancer. In patients with breast cancer,...

Equipotent Generation of Protective Antitumor Immunity by Various Methods of Dendritic Cell Loading With Whole Cell Tumor Antigens.

Journal of immunotherapy : official journal of the Society for Biological Therapy

Lambert LA, Gibson GR, Maloney M, Barth RJ.
PMID: 11395638
J Immunother (1991). 2001 May;24(3):232-236.

Multiple clinically applicable methods have been used to induce dendritic cells (DCs) to express whole cell tumor antigens, including pulsing DCs with tumor lysate, and mixing DCs with apoptotic or live tumor cells. Herein we demonstrate, using two different...

Showing 1 to 12 of 29 entries